Cethromycin Against Liver-Stage Malaria (CALM)
Eliminating Malaria Relapse Without Testing Barriers
"Radical cure" in malaria refers to the complete elimination of all parasites from a patient's body, specifically targeting the dormant liver stages (hypnozoites) of Plasmodium vivax and Plasmodium ovale to prevent disease relapses. This contrasts with standard blood-stage treatments that only address acute symptoms but leave the dormant parasites untouched.
Cethromycin HCl is a short-course, Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency testing-independent oral therapy designed to eliminate dormant liver-stage malaria and prevent relapse—without the safety and deployment constraints of current radical-cure options.